Iranian Journal of Materials Science and Engineering
Iran University of Science & Technology
Fri, Oct 31, 2025
[Archive]
Nima Hoseinizadeh 
, Farzaneh Kiarad , Zahra Kiani , Abolfazl Sadeghi , Azadeh Taherpour , Mehdi Shakibaie
, Farzaneh Kiarad , Zahra Kiani , Abolfazl Sadeghi , Azadeh Taherpour , Mehdi Shakibaie
Abstract: (102 Views)
Glioblastoma multiforme is an aggressive brain tumor with limited therapeutic options. This study evaluated the multifunctional anticancer effects of curcumin-synthesized silver nanoparticles (curcumin-AgNPs) on the U-87 glioblastoma cell line. Curcumin-AgNPs were biosynthesized using curcumin as a reducing and stabilizing agent and characterized by ultraviolet–visible spectroscopy (UV–Vis), dynamic light scattering (DLS), and transmission electron microscopy (TEM). Cytotoxicity was assessed by MTT assay. The mRNA expression of apoptosis- and epithelial–mesenchymal transition (EMT)-related genes was quantified by real-time PCR. DLS and TEM analyses revealed curcumin-AgNPs with sizes of 56.27±4.59 nm and 22±3 nm, respectively. Curcumin-AgNPs reduced U-87 MG cell viability in a dose- and time-dependent manner. Analysis of apoptosis-related genes showed an increased BAX/BCL2L1 ratio. Additionally, FN1 and VIM were downregulated to 0.48- and 0.60-fold, respectively, indicating inhibitory effects on EMT and the metastatic potential of U-87 MG cells. These findings indicated that curcumin-AgNPs exhibit cytotoxic, pro-apoptotic, and EMT-modulating effects in U-87 MG cells, highlighting their potential as a multifunctional nanoplatform for glioblastoma research. Further studies are required to elucidate their underlying mechanisms.
Type of Study: Research Paper |
Subject:
Biomaterials
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